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̈Zr[, <strong>7</strong>, e008 (2018)@<a href="http://dx.doi.org/10.7875/leading.author.7.e008">DOI: 10.7875/leading.author.7.e008</a>
Ryuichi Nishihama & Takayuki Kohchi: <strong>The liverwort <em>Marchantia polymorpha</em>: an emerging model organism.</strong>

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<h2>v </h2>
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<h2>͂߂</h2>
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<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2018/09/Kohchi-7.e008-Fig.1.jpg" target="_blank">[Download]</a></div>[hs_figure id=1&amp;image=/wordpress/wp-content/uploads/2018/09/Kohchi-7.e008-Fig.1.png&amp;caption=fig1-caption-text]

@V[NGT[̕yɂZԂRXgŃQmǂł悤ɂȂƁCA̐i𕪎q̌tŐ錤ɂȂĂDqn͂ɂȀڍׂȌn֌W炩ɂCȂl̗͊iiɐi񂾁D20I㔼ɂ͕qw䓪Dqw̃fɂƂ߂dvȗvƂāC`]\ł邱ƁC`wIыt`wIȉ͂\ȂƁCāCQmǂĂ邱ƂDׂĂ݂AƂāCoqtÃVCkiYii<em>Arabidopsis thaliana</em>jPqtÃCli<em>Oryza sativa</em>j͂₭CƂ1990Nォ2000NɂǍ͂烂fAɏWD̐헪͐CCCȂǂɂĂ̖cȒm炳A̗ɑ傫vD̂̂CΑ̃N~hiXi<em>Chlamydomonas reinhardtii</em>jRPÃqcKlSPi<em>Physcomitrella patens</em>jfAƂĊmꂽƂ́CA̐ǐɂꗢ˂łC葍Iȋc_\ɂȂDŁCfAɌ`⌻ۂ݂ȂC邢́CGȂǂ̗RɂC𖾂łdvȖA̕ɂ͑cĂD̂悤ȖɎgނɂ́Cł邾lȌnɑΏۂƂKvD܂ނق̌nƓlɁCAɂĂỉߒŃQm̏dNC`q̋@\̏璷C@\̕SisubfunctionalizationjV@\̊lineofunctionalizationji񂾂ƂlƁCł邾Pȑ̐Qmɒڂ̂͂ЂƂ̕ł낤DIȐ̃fƂĂ̑咰ہC^j̃fƂĂ̍yꂪCw̐iWɂ͂ɂĂ͏qׂ܂łȂD
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<h2>1D[jSP̐wIȓ</h2>
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<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2018/09/Kohchi-7.e008-Fig.2.jpg" target="_blank">[Download]</a></div>[hs_figure id=2&amp;image=/wordpress/wp-content/uploads/2018/09/Kohchi-7.e008-Fig.2.png&amp;caption=fig2-caption-text]

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@[jSṔC8{̏F̂1{̐FX邢Yi1{̐̐F̂UVƂԂƂ񏥂ĂjYꂼꂪD2017NCۗނ͂͂߂āC[jSP̑SQmz񂪔\ꂽ<a href="#R21"><sup>21)</sup></a>D[jSP̃Qm̉ǂ́CI[XgAMonashw̌O[vƕM҂̋vƂĕčJoint Genome InstituteɂĊJnC͍͂O50̌O[vɂi߂ꂽĎʁC225.8 MbJo[3000̃XLbtH[hɖ19,000̈`qoꂽDłɉǂĂYF̂ɂ킦<a href="#R22"><sup>22)</sup></a>CXF̂̔z炩ɂꂽD܂CM҂͍`w̌O[vƋMarpolBaseiURLF<a href="http://marchantia.info" target="_blank">http://marchantia.info</a>jJDMarpolBaséC`q̍\CCȂǂɊւ񋟂@\C`qz̎擾AVXg@\CQmҏŴ߂̃KChz̐݌vvOCȂǂ[U[th[ȃ[jSP̃Qmf[^x[XłD́CAme[Vɏ[ĂƂƂɁCgXNvg[GsQmȂǂɊւ邳܂܂ȏ{ł悤XVĂ\łD
@[jSP̃Qm̂Ƃ傫ȓ́CÂ]ʈqVOi`BqȂǂR[h鐧n̈`qقڈʂCC̏璷ɒႢƂłDÂ50̓]ʈqt@~[̂C[jSPɂ47oꂽDVCkiYiɂ͖2000̓]ʈq̈`q݂邪C[jSP398iF̂387CXF̂7CYF̂4jCقƂǂ̏ꍇCet@~[̃Tut@~[ƂɂЂƂ邢͏̈`qێ<a href="#R21"><sup>21)</sup></a>D͓]ʈqɂ萧䂳邱ƂlƁCqԂȂǂ̔́CVɊl]ʈqɂ`qlbg[NtꂽƂCłɂĂ]ʈq̈`qlbg[N̓]pC`qd̂̂̋@\̕S邢͐V@\̊lɂƂ낪傫ƎD[jSPɂ͉ԉ胁Xě`ɕK{LEAFYt@~[Ԋ튯̌`ɒSIȖ͂MADS{bNXt@~[݂邱ƁCāCMADS{bNXt@~[̔qAɂ锚Iȑ́Ĉ悤Ȑi̗l@ɕD

<h2>2D[jSP̎n</h2>
@̕WƂTakaragaike-2iTak-2jCY̕WƂTakaragaike-1iTak-1jgĂDQm̉ǂɂTak-2Tak-1̎G1Tak-14߂zp<a href="#R21"><sup>21)</sup></a>D[jSP͐ƂĊV|n܂ޗêȂŖۓIɐ炳邱ƂłDŝ̃tB^[t|{ep邱ƂɂCB̕lHzCEqX̌`܂łsDꂽEq̂܂܊V|nɂ܂ƂɂCŋۍƂȂɎ̖ی̂擾łDœꂽψّ̂`]̂Ȃǂ̊̒̕ۑ͑؂łD[jSP͖Eq△ȂǁCƂƒԂɂ킽ێזE튯C͊ȒPȏ邱ƂŗⓀɂ①ɂɂĔNPʂŕۑłDŋۏEq̌tŝ̊p邱Ƃœۑ\łDŋ߁CזEKXt̒fɂĕۑ邱Ƃɂ薳t̂𔼉ivIɕۑ@Jꂽ<a href="#R23"><sup>23)</sup></a>DɁCq̓ۑ@Jꂽ<a href="#R24"><sup>24)</sup></a>DApłێłȂ̂ł΂ɑ̘J͂₳˂΂ȂȂC[jSP͑؂Ȍ̈ێȒPłD
@[jSP̌҃R~jeBɂďFꂽ`q@ш`q^\L@ɂẮC<a href="#R25"><sup>25)</sup></a> QƂꂽD
@`]\ł邱Ƃ́CfƂĂ̍ő̗vłƂĂߌł͂ȂD[jSPɂĂ̓AOoNeEpȌ`]@J<a href="#R26"><sup>26)</sup></a>C܂܂Ȏ\ɂȂD̎@͖Eq̂p̂ŁCЂƂ̖EqX1000ȏ̓Ɨ`]̌nDT-DNA^MO@ɂψّ̂̒TĈɏqׂ鑊gɂ`q̔jȂǁCʂ̌`]̂𓾂KvƂɂ͂̎@pDCEqp邽߁C`]͎̂Ye̍`IȔwiƂɒӂKvDɁCt̂̒fЂɌ`Đɑ΂AOoNeEpDNA𓱓@Jꂽ<a href="#R17"><sup>17)</sup></a>D́CqAɂėp郊[tfBXN`]@ƓlɁCA̍Đ\𗘗p̂łDŠ`]̂ǂɓ邱Ƃɂ͂ނȂCłɊm`]̂ȂǓ̊DNA𓱓ł邱ƁC܂CEq擾Kv̂ȂƂȂǂ_łD[jSPƃAOoNeE̋|{ƁD̂̂̃AOoNeE̐C܂ɂI܂ŁCV|nւ邱ƂȂ1łׂčsAgarTrap@Ƃ@񍐂ꂽ<a href="#R27"><sup>27)</sup></a>DEq́Ct́CȂǁC܂܂ȍזEgDɓKpĂD
@܂łɁCAOoNeEɂ`]ɗp邽߂̎X̃oCi[xN^[\zꂽDIɗp܂ƂẮCnCO}CVCQ^}CVCNXtCG4184ނDɂẮC̊O`q𓱓ꍇD[jSPɂẮCقȂoCi[xN^[AOoNeEĖEq̂Ɋ邱ƂɂCď`]̂ǂɎ擾łD2ނ̃xN^[pꍇC̃xN^[̖܃}[J[pēꂽ`]̖̂3ɁC̃xN^[<a href="#R28"><sup>28)</sup></a>D̖̓܃}[J[̃xN^[pāCď`]̂`q^CsOȂǂɂI邱Ƃ\łC邱ƂŃ}[J[ߖłD
@Cӂ̈`qCP픭v[^[Cu^pN^OCGsg[v^OC|[^[ȂǂGatewayZppėZł悤ɂpMpGWBoCi[xN^[V[YC4ނ̖܃}[J[ׂ̂Ăɂč쐻ꂽ<a href="#R28"><sup>28)</sup></a>DߏȔɂ萶炪jQ悤Ȉ`q́CPIȃv[^[ł͍ߏȔ̂𓾂邱ƂłȂDɂ́CUIȔLłD]ʈqȂǊjɂċ@\^pN̏ꍇɂ̓ORR`RChêƂ̗Z^pNnLłCpMpGWBoCi[xN^[V[YɊ܂܂D`]̂ɃfLT^]邱ƂɂCړĨ^pN̊jւ̈ڍsЂNDזEIKlȂǂɂċ@\^pNCmiRNAȂǂRNAUIɔꍇɂ̓gXAN`x[VnLłCXVEn[jSPpɉςxN^[񍐂ꂽ<a href="#R29"><sup>29)</sup></a>DlH̓]ʈqXVE𔭌CGXgWI[邱ƂɂړÏ`q̓]ʂUD
@^pN̋@\͂邤ŁCזEɂǍ݂m邱Ƃ͏dvłD܂łɁCj<a href="#R28"><sup>28)</sup></a>CזE<a href="#R28"><sup>28,30)</sup></a>CtE<a href="#R30"><sup>30)</sup></a>CE<a href="#R28"><sup>28,30)</sup></a>CSW<a href="#R30"><sup>30)</sup></a>CgXSWlbg[N<a href="#R30"><sup>30)</sup></a>CyILV\[<a href="#R31"><sup>31)</sup></a>C̖<a href="#R30"><sup>30)</sup></a>CFAN`<a href="#R31"><sup>31,32)</sup></a>C<a href="#R31"><sup>31,33,34)</sup></a> Ȃǂ̍\IKlɋǍ݂^pN񍐂ĂC̉͂ɂă}[J[ƂĎgƂłDł́CזEєǂ̗i<a href="#F3">}3</a>jD

<a name="F3"></a><div id="fig3-caption-text" style="display: none;"><strong>}3@[jSP̍זEɂǍ݃}[J[̗</strong>
iajזẼ}[J[ɂCitriněuDñmb`̕t߂D
ibjǂ̃}[J[ɂCitriněuD1ڂ̖̃mb`̕t߂D[ ] ͑OOǑC͋Ɍ`́CS͖áCP̓tOvXgD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2018/09/Kohchi-7.e008-Fig.3.jpg" target="_blank">[Download]</a></div>[hs_figure id=3&amp;image=/wordpress/wp-content/uploads/2018/09/Kohchi-7.e008-Fig.3.png&amp;caption=fig3-caption-text]

@`q̋@\̗ɂāCψّ̂̕\^̉͂瓾͑D`q݂ȂC܂͂̕ψّ̂𓾂邱Ƃlł낤D̂߂ɂ́Ct`wIȃAv[`ȂDpȌȂ[jSPɂẮCP܂͏̈`qj󂷂邾ŕ\^邱Ƃ̑̂_łCɒڂD[jSPɂĈ`q̔j\ɂŏ̎@́Cg𗘗p`q^[QbeBOɂmbNAEgł<a href="#R35"><sup>35)</sup></a>D3`4 kb̑A[z̖̓܃}[J[ɂ鐳̑IƁCA[z̊O̒v`qɂ镉̑IƂgݍ킹邱ƂɂCWIƂȂ`qIɃmbNAEgꂽIłDςƁC̑Iʉ߂`]̖̂1̃mbNAEgD܂ŁC\̂̂܂߂̎@ɂ100߂`qj󂳂ꂽDʏC100̈ȏ̌`]̂`q^CsOKv邽߁CEq̂̌`]pKvD
@`qjƓŃ^pNC[Citrine܂TagRFP𓱓mbNCxN^[쐻ꂽ<a href="#R20"><sup>20)</sup></a>D̎@Ŏ擾銔͕WIƂȂ`q̍ʂu^pNƂ̗Z^pN𔭌̂ŁC{̔ɋ߂ŕWIƂȂ^pN~ςזEgD̓肨эזEɂǍ݂̉͂sDpMpGWBxN^[ȂǂpāC̈`q̃v[^[+R[fBOz+u^pN+^[~l[^[O`qƂēĂCT-DNȂ}ʂ̃|WVʂɂ锭̂΂C̈悪܂܂ĂȂȂǂ̗RCmȔp^[𖾂łȂƂXɂDO`qƂĂ͔oȂCmbNCł͌oꂽDC݂̃xN^[͍\C3f|̈您у^[~l[^[ɂ鐧͂͂炩ȂƂɗӂKvD܂Ĉ݂ƂCN[Ƀ^OmbNCn͍\zĂȂD͍̉ۑłD
@GhkNA[[ɂ蕔ʓٓI2{DNAؒf𓱓C񑊓[⑊gȂǂɂC𗘗păQmzςQmҏWZṕC̎ɂĈ`qς\ɂDȂłCȕւƉp͈͂̍LCŋ߂CRISPR-Cas9p@嗬ƂȂĂD[jSPɂẮC2014NCRISPR-Cas9ɂQmҏW񍐂ꂽ<a href="#R36"><sup>36)</sup></a>DCQmҏW̌͒ႭCWIƂȂ`q̕ψّ̂̕\^wWɂĂ悤₭QmҏW̋N𓯒łxłDM҂́CVCkiYiɃRhœKCas9p邱ƂɂC\^wWɂƂCׂɑI`q^CsO邱ƂɂQmҏW̋N𓯒ł郌xɂ܂ŃQmҏW̌iiɏ㏸@J<a href="#R37"><sup>37)</sup></a>DJZbgɌ悭KChRNAN[jOłGg[xN^[ƁCCas9̔JZbgGatewayJZbg̗oCi[xN^[̌n\zCGatewayJZbgKChRNA̔JZbgɑgP̃oCi[xN^[ɂ蓾`]̂10̂قǈ`q^CsO΁CĂ̏ꍇČ̂ɂăQmҏWmF悤ɂȂD̂悤ɂēꂽQmҏW̋NɂĂCas9уKChRNAPIɔÂ邪Cꎩ̂̓[jSP̐ɉeڂƂ͂ȂC܂CIt^[QbǧƗ\zzɂҏWF߂ĂȂD܂C2̃KChRNA𔭌邱ƂɂĈ̗̈傫邱Ƃɂ<a href="#R37"><sup>37)</sup></a>D
@2{̐ɂẮCK{ƂȂ`q̕ψق̓weڍ̂ƂĈێCŃzڍ̂Ƃĕ̂ɂāiŏɕK{̋@\𔭊锭̒iḰj\^͂邱Ƃ\łDC1{̐ɂĂ͕K{ƂȂ`q̕ψّ͎̂擾łȂD͂̑ΏۂƂȂ`qזE̐ɂƂK{̋@\ꍇC܂Cɂĕ̔̒iKɂĕK{̖͂ꍇɂ́Cł݂̂̈`q̋@\rψّ̂KvłDɏqׂXVEnpĐlHmiRNA𔭌邱ƂɂC܂ɂUIɕWIƂȂ`qmbN_Eł邱Ƃꂽ<a href="#R29"><sup>29)</sup></a>D̗}̃x͌nɂقڊSȂ̂畔IȂ̂܂ł܂܂łC܂C܂̔ZxɂĂ}̃x͐łƍlCL\^ώ@łD
@M҂́Cʂ̎@ƂāCIɈ`q邱Ƃ̂ł銔1̌`]ɂ擾@J<a href="#R37"><sup>37)</sup></a>i<a href="#F4">}4</a>jD́CCRISPR-Cas9ɂWIƂȂ`qւ̕ψق̓ƁCIɏ\ƂWIƂȂ`q̑̂߂̃gX`q̓𓯎ɍŝłDWIƂȂ`q̑̂߂̃gX`q̓KChRNAɑϐłKvCA~m_zωȂ悤`u𓱓邱ƂɂϐD܂CKChRNAGL\ƃCg̃WNVɐ݌vł΁C쐶^cDNÂ܂ܕWIƂȂ`q̑̂߂̃gX`qƂėp邱ƂłCƂȕւłDWIƂȂ`q̑̂߂̃gX`q̏ɂCre-<em>lox</em>Pnɂ镔ʓٓIȑgpDORR`RChêƗZCregyfR[h`qMVbNv[^[ƘA邱ƂɂCfLT^]̏єMVbN2̏ɂC̏ȂIȑg̗Uꂽ<a href="#R38"><sup>38)</sup></a>DIȃmbNAEgƂėpɂ́Cł邩1Rs[œꂽgX`qCCre-<em>lox</em>Pnɂǧ̍I邱ƂdvłD

<a name="F4"></a><div id="fig4-caption-text" style="display: none;"><strong>}4@[jSP̏IȃmbNAEg̊T</strong>
iajIȃmbNAEg̍oDCas9ѕWIƂȂ`q̃KChRNA𔭌CRISPRxN^[ƁCKChRNAɑϐWIƂȂ`q̑̂߂̃gX`qicDNAj𔭌xN^[pēɌ`]sDgX`q𔭌xN^[́CORR`RChêƗZʓٓIȑgyfCreiCre-GRjMVbNv[^[ɂ蔭JZbg܂ށDꂽ`]̂CWIƂȂ`qɃQmҏW̋NIďIȃmbNAEgoD
ibjmbNAEg̗UDoIȃmbNAEg𐶈炳CCӂ̃^C~OŔMVbNуfLT^]ɂ菈邱ƂɂCORR`RChêƗZʓٓIȑgyfCre̔ъjւ̈ڍsЂNCWIƂȂ`q̑̂߂̃gX`q̌UD̋NזE͌u^pNitdTomato-NLSj̔ɂD
<a href="http://leading.lifesciencedb.jp/wordpress/wp-content/uploads/2018/09/Kohchi-7.e008-Fig.4.jpg" target="_blank">[Download]</a></div>[hs_figure id=4&amp;image=/wordpress/wp-content/uploads/2018/09/Kohchi-7.e008-Fig.4.png&amp;caption=fig4-caption-text]


<h2>3D[jSP̗_̗</h2>
@[jSPp邱ƂɂC`q㉻ɂ͂C`qt@~[̗Aɂ@\␧̐iɂāC܂܂Ȓm𓾂邱Ƃ҂D̂悤Ȏ_ɂāCȉCqׂD
@[jSP͎Yيł邽߁CBC킨ёCѐqƂB튯zq̌`𐧌䂷@\ɂāC΂̐̉e邱ƂȂ͂łD܂CB튯rIeՂɎoW߂ł邱Ƃ[jSP̓łD킦āCq̌`@\̉͂ɑ΂q`wIȃAv[`Kpł邱Ƃ<a href="#R39"><sup>39-42)</sup></a>C܂߂ȊwɂĖ͓IłDɁĈɏqׂ悤ɁC[jSPɂĂ͌ƗLBԓIIɊSɐ؂藣ĂD́CۊǑA⓮ɂLB̋@\Ƃ͈قȂ傫ȓłC̉͂ɂ͊iD̍ޗƂD̂悤ȔwiƂɁC[jSP̗LBɊ֘AɂȂĂD
@z̖̐͂̂Ƃzq鐢łCEq͂܂Czq̌`ւāC󐸂܂łDqAɂĔz̐͋ɓxɏkނCԓIɂɒZi<a href="#F2">}2</a>jDɂ萶EqяEqXщԕ`Cꂼꐔ̑̍זEւĔzq𕪉D̍ہCEqł͊ĵ݂8ɑ̂ɍזEɂ藑זE⒆זE𐶂̂ɑ΂CEqł͔Ώ̕ɂ傫h{זEƏYזEƂɕCYזEh{זEɎ荞܂ꂽ̂ɋϓ􂵂2̐זEɂȂD󕲂̂̂ԕǂLXɒBƁCԕǂoꂽזEЂƂזEђזEƎ󐸂d󐸂NCz̐͏IDC[jSP͖Eq肷ƂɍזE􂵗t̂`ĉh{邽߁Czq̌`Jn܂ł̎Ԃi<a href="#F2">}2</a>jDĈ悤ȗLBւ̈ڍs͌≷xȂǂ̊̎hɈˑ邽߁CK؂ȏȂzq͌`ȂD[jSP̉͂ɂC[jSP̓ɈˑIȔzq̌`ƔqẢԐƂ̂ɐq̋ʐoꂽ<a href="#R18"><sup>18)</sup></a>D܂CɈˑIȐ݂͔̂z̐ɂĔCA̐ỉߒɂĖEq̐̐̓]ɓ]pꂽƂ炩ɂꂽ<a href="#R18"><sup>18,43)</sup></a>D̂ɁCRPAɂ͂ȂԂ炩邽߂̂܂܂ȂEq̐ɒǉꂽƂzD܂CRPAɂĂ͔zq̌`̂̂ɂ̃XebvD܂CBi킨ёj̒P̎nזEK肳Dꂪ̃p^[ŔΏ̕􂷂邱ƂɂC͔zqɂȂO̍זEƂƂ肩ރWPbgזEDO̍זÉCɂĂ͂Ȃ鐔̔Ώ̕ւėזE𐶂DYɂĂ͓IȍזEɂזE𑝉̂CIȑΊp̕̕ɂ肨̂̂̍זE͐qɕ<a href="#R44"><sup>44)</sup></a>D
@2016NCO2̌O[vɂ肠ŁC]ʈqłRKDi[jSPɂẮCMpRKD̂ЂƂ̂݁j[jSPɂėזE̐̕ɂƕ񍐂ꂽ<a href="#R42"><sup>42,45)</sup></a>DMpRKD̋@\ɂĂ͗זȆÔ͌`ꂽ̂́CזE͐nnȂ܂܍זE􂪋ND2017Nɂ́CVCkiYiɂĂRKD̃̕zOzq̔ɂċ@\邱Ƃ񍐂<a href="#R46"><sup>46)</sup></a>CRKD͐iIɕۑꂽ@\Ƃ킩DɁCYzq̌`̉ߒڍׂɊώ@ăXe[WɕƂƂɁCɂgXNvg[͂{ꂽDԕ␸זE̔邢͕ɂ`qꂼٓIȃXe[WɂĔĂƂCYzq̌`̋@\͐ỉߒɂđgł͕ۑĂ邱Ƃꂽ<a href="#R39"><sup>39)</sup></a>D
@āCA̐Bn͂ǂ̂悤ɋK肳̂ł낤DqAɂEq̌`zq̌`܂ł̒ZԂł́CBn̋KƔzq̕قړɋN邽߂̋ʂ͂͂肵ȂDŋ߂̃[jSPpɂCMpBONOBOƖꂽwbNX-[v-wbNX^̓]ʈq̋@\B̌`ɕKv\ł邱ƁCMpBONOBO͐B̎nזEєzq̑O̍זEɂĈߓIɒ~ς邱Ƃꂽ<a href="#R20"><sup>20)</sup></a>DVCkiYĩI\OƂČoꂽBNB1BNB2̓dɂẮCEq̔Ώ͋̕N̂́CזEYזEƂċ@\ȂȂDɁCBNB2͏זEɂĈߓIɒ~ς<a href="#R20"><sup>20)</sup></a>Dȏ̂ƂCMpBONOBÕzO͔z̐ɂĐBnK肷iIɕۑꂽ]ʈqłƍlꂽD[jSP̔N_ƂāCAɂċʂ̌oꂽDłDMpBONOBÕzO̔ɍlƁCRPAɂĂ݂CEqh{ւĐBזĚn񂪌܂܂ł̊ԂƁCBזĚn񂪋K肳Ăzq`܂ł̊ԂCqAɂĂ͂ǂ1̍זEɏkނƂi<a href="#F2">}2</a>jD[jSPɂĂMpRKDq̌`ɂĂK{ł͂ȂdvȂ͂炫邱ƂĂ邪<a href="#R42"><sup>42)</sup></a>CVCkiYiɂĂRKD̗Yzq̌`ւ̊֗^͎ĂȂƂC̋@\͏kނ̉ߒŎꂽ\D
@[jSP̃Qm͐n̈`qɂĈ`q̏dȂDVCkiYiClȂǔqÃfɂāC錻ۂւ̊֗^͂킩Ă̂̍璷Ȃǂ̗R܂\ɉ𖾂ĂȂ`q̋@\₵݂ɂāC[jSP͂̉𖾂ɍv\Dɂ킦āC`qdɂ萶pŐ@\̕SV@\̊lɂĐiIȓ؂𗝉̂ɂKĂDD̓tBgNłDqAɂătBgNI^II^ɑʂDI^͌̏Ǝ˂ɂ}ɕ̂ɑ΂CII^͌ɑ΂łD܂CI^͐ԐFƉԐF̂ǂ̏Ǝ˂ɂĂjɈڍŝɑ΂CII^͐ԐFɂĂ̂݊jɈڍsƂႢD[jSPɂāCtBgNMpphŷЂƂ݂ȂCMpphy͌萫CCjւ̈ڍs͐ԐFƉԐF̂ǂłN邱ƂCI^II^̓킹Ƃ炩ɂꂽ<a href="#R15"><sup>15)</sup></a>DɁCI^͒ʂ̉щԐF̍Ǝ˂̉ɁCII^͐ԐFƉԐFƂ̉tʂ̉ǂ邪CMpphy͒ʂ̉łȂ<a href="#R15"><sup>15)</sup></a>Cŋ߂̉͂CԐF̍Ǝ˂̉ɂĂ@\邱Ƃ킩ĂD̂悤ɁCƂƂ͂ЂƂŒʂ̉ƉԐF̍Ǝ˂̗̉𐧌䂵ĂCA̐ỉߒC炭CqȂ̕OɁCpŐ@\̕SiI^II^jѐV@\̊liʂ̉jNƂꂽ<a href="#R47"><sup>47)</sup></a>D
@VȂ݂`q̐V@\Ȃǂ̈ӊOȔ́C`wIȉ͂ɂ炳邱Ƃ悭D[jSPɂĈ`q̏璷ႢƂ́C`wIȃAv[`Lł邱ƂӖDɏqׂMpBONOBOCB̌`ɉԐFKvƂȂψّ<a href="#R48"><sup>48)</sup></a> ̐ӔC`q̎YƂē肳ꂽDT-DNA^MO@pψّ̂̒TѐӔC`q̓sĂCČ`ɕK{<em>MpNOPPERABO1</em>`q͂<a href="#R49"><sup>49)</sup></a>C̈`q肳Ă<a href="#R13"><sup>13,50,51)</sup></a>DḾׂCT-DNA^MO@ɂ336,000̌`]̂TC̐Lɂ33̈`q𓯒肵ł<a href="#R51"><sup>51)</sup></a>Dł́C1XN[jOɂ301̉̐LsS̕ψّ̂PCzł165̂62T-DNÃnCO}CVϐ`qƘAĂƕ񍐂ꂽDɁĈ57T-DNȂ}ʂTAIL-PCR@ɂ蓯肳ꂽD܂CwψٌK}pˑRψق̗U\łC\ł͂邪C܂łɕM҂͋[\^ψّ̂𓾂ĂD1ĕψّ̂T͍̂̐܂Ƃł邪CƂ΁Cψّ̂炷ł̒Tł΁CT-DNA^MO@ɂ`]̂G`^Xz_Ȃǂ̕ψٌɂ菈̂𐔑T邱ƂłDM҂́CT-DNA^MO@ɂ200,000̌`]̂̂ȂCZx̃I[LVɑϐψّ̂̂ЂƂƂMp<em>ARF1</em>`q̑}ψيPo<a href="#R13"><sup>13)</sup></a>D

<h2></h2>
@̃r[ɂẮC[jSP̃fƂĂ̓ɂďqׂĂCłƂ肠ƈȊOɂC܂܂ȐזẼfƂėLłDہCAzCyv`hɂזEԃR~jP[VCCזEiCaQۂւ̉ȂǂɂĂ̌iłCǍ͐HƂƂĂ̔qAɏWł邪CnK͂̊Ȃǂɖڂނ΁CȂŜӎ܂܂Ȏ̒mrȂ瑍Iɍl@邱Ƃɂ݂Ă邱ƂDQmƃc[̂[jSP炷v́Cꂩ܂܂傫ȂĂƗ\zD݁CRPÂfAƂĎpIȂ̂̓qcKlSPу[jSPł邪C[jSP̎@c[͂ق̃RPA̋@\̉͂ɂ]pł邩ȂDCɑ̃RPAC܂CV_AΑɂĂfi߂΁CA̗㉻î݂ɂĂ̗͋}ɐ[܂ł낤D
@^CggfhƂ̂́C[jSP̓fAƂĂłȂCSʂ̃fƂĂpłƍlĂ邩łDlȃc[CvɎ̂ł[jSPזẼnRƂėpāC܂ނق̐ɗR`q𔭌邱ƂɂCȂ\Ȃ蔽nȂY邢͍č\z邱Ƃ͔rIeՂłD̂悤ȐHwI邢͍wIȗpCȊwɂ邳܂܂Ȍ̃vbgtH[ƂĂ̊pLpł낤D܂C𗘗pψّ̂̒T́CI[LV̗ႾłȂق̉ɂKp\ŁCP~JoCIW[Ƃ̑悢ƍlDƂ΁CŐɑ΂ϐψّ̂𓾂邱ƂɂC̉̍p@̗i邾낤D1{̂Ŏ̂łyƓ悤ȊoŃ[jSPp邱ƂɂCqA⓮ł͓邱Ƃ̂ނmɂǂ\D
@ڂ̂ǂ낵ŁC܂܂ɁCāCyɊpł̂[jSPłD̃r[ꂩ̌ޗlꏕƂȂ΍KłD

<h2> </h2>
<ol>
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</ol>
<div class="au-profile">
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<span class="author">l iRyuichi Nishihamaj</span>
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